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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores

For example, pairing glutamine (Gln) antagonists with immune checkpoint inhibitors might lead to better treatment results

On the other hand, the peritoneal mesothelial cells with insufficient IGF-1R expression had lower migration ability and higher adhesion ability (74)

Our findings indicated that DA D1R activation was involved in Gln synthesis (Fig